Drug interactions
Amlodipine-olmesartan + Dronedarone
Severity: Moderate
Amlodipine-olmesartan and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and may raise amlodipine exposure, increasing hypotension and edema. Dronedarone also depresses sinus and AV node function, and calcium channel blockers can add to bradycardia and conduction slowing, although amlodipine has little nodal effect.
What this interaction means in plain words
Amlodipine-olmesartan and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Dronedarone belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition by dronedarone increases amlodipine levels, with additive hemodynamic and conduction effects.
What to do
Monitor blood pressure, heart rate and edema, and review an ECG after starting dronedarone. Reduce the amlodipine dose if hypotension or edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Dronedarone?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and may raise amlodipine exposure, increasing hypotension and edema. Dronedarone also depresses sinus and AV node function, and calcium channel blockers can add to bradycardia and conduction slowing, although amlodipine has little nodal effect.
How serious is the interaction between Amlodipine-olmesartan and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and review an ECG after starting dronedarone. Reduce the amlodipine dose if hypotension or edema develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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