Drug interactions
Amlodipine-olmesartan + Eplerenone
Severity: Major
Amlodipine-olmesartan and Eplerenone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ARB with a mineralocorticoid receptor antagonist raises the risk of clinically significant hyperkalemia and renal function decline. The risk is highest in older patients, diabetics and those with reduced renal function.
What this interaction means in plain words
Amlodipine-olmesartan and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan belongs to Cardiovascular; Eplerenone belongs to Cardiovascular.
Why it happens
Additive reduction of renal potassium excretion through angiotensin II receptor blockade and aldosterone receptor antagonism.
What to do
Check serum potassium and creatinine at baseline, within the first week or so, and periodically thereafter. Avoid potassium supplements and reduce or stop eplerenone if potassium rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Eplerenone?
MediHelp rates the interaction as major. Amlodipine-olmesartan and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ARB with a mineralocorticoid receptor antagonist raises the risk of clinically significant hyperkalemia and renal function decline. The risk is highest in older patients, diabetics and those with reduced renal function.
How serious is the interaction between Amlodipine-olmesartan and Eplerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and creatinine at baseline, within the first week or so, and periodically thereafter. Avoid potassium supplements and reduce or stop eplerenone if potassium rises significantly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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