Drug interactions
Amlodipine-olmesartan + Esmolol
Severity: Moderate
Amlodipine-olmesartan and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol adds to the blood pressure lowering effect of amlodipine and olmesartan, which can cause hypotension and bradycardia. Esmolol is given intravenously in monitored settings, so the effect is short-lived and manageable.
What this interaction means in plain words
Amlodipine-olmesartan and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic hypotensive effects from beta-1 blockade, vasodilation and renin-angiotensin blockade.
What to do
Monitor blood pressure and heart rate continuously during esmolol infusion and titrate the infusion rate downward if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Esmolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol adds to the blood pressure lowering effect of amlodipine and olmesartan, which can cause hypotension and bradycardia. Esmolol is given intravenously in monitored settings, so the effect is short-lived and manageable.
How serious is the interaction between Amlodipine-olmesartan and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during esmolol infusion and titrate the infusion rate downward if hypotension or bradycardia develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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