Drug interactions
Amlodipine-olmesartan + Ethacrynic acid
Severity: Moderate
Amlodipine-olmesartan and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a loop diuretic that causes potassium loss, whereas olmesartan tends to raise potassium and can also cause hypotension in volume-depleted patients. Together they may produce volume depletion, hypotension and renal function changes, while the net potassium effect is unpredictable.
What this interaction means in plain words
Amlodipine-olmesartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Loop diuretic-induced natriuresis and kaliuresis combined with angiotensin receptor blockade, which reduces aldosterone-mediated potassium excretion and lowers blood pressure and glomerular filtration pressure.
What to do
Monitor serum potassium, creatinine and blood pressure after starting or changing doses. Watch for volume depletion and adjust the diuretic dose if hypotension or renal impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Amlodipine-olmesartan with Ethacrynic acid?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a loop diuretic that causes potassium loss, whereas olmesartan tends to raise potassium and can also cause hypotension in volume-depleted patients. Together they may produce volume depletion, hypotension and renal function changes, while the net potassium effect is unpredictable.
How serious is the interaction between Amlodipine-olmesartan and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and blood pressure after starting or changing doses. Watch for volume depletion and adjust the diuretic dose if hypotension or renal impairment develops.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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