Drug interactions
Amlodipine-olmesartan + Flibanserin
Severity: Moderate
Amlodipine-olmesartan and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise flibanserin levels. Flibanserin can cause hypotension, syncope and sedation, and these effects may be increased with multiple weak CYP3A4 inhibitors.
What this interaction means in plain words
Amlodipine-olmesartan and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Weak CYP3A4 inhibition by amlodipine reduces flibanserin metabolism, with additive hypotensive effects.
What to do
Monitor for dizziness, hypotension and somnolence, and avoid adding further CYP3A4 inhibitors. Counsel the patient to avoid alcohol and take flibanserin at bedtime.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Flibanserin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise flibanserin levels. Flibanserin can cause hypotension, syncope and sedation, and these effects may be increased with multiple weak CYP3A4 inhibitors.
How serious is the interaction between Amlodipine-olmesartan and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, hypotension and somnolence, and avoid adding further CYP3A4 inhibitors. Counsel the patient to avoid alcohol and take flibanserin at bedtime.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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