Drug interactions
Cobicistat + Flibanserin
Severity: Contraindicated
Cobicistat and Flibanserin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and markedly raises flibanserin concentrations. This can cause severe hypotension, syncope and profound sedation.
What this interaction means in plain words
Cobicistat and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Flibanserin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 metabolism of flibanserin increases its exposure.
What to do
Do not coadminister. Avoid starting flibanserin until at least 2 weeks after stopping the inhibitor.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
- Cyclosporine + Flibanserin Contraindicated
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Flibanserin?
MediHelp rates the interaction as contraindicated. Cobicistat and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and markedly raises flibanserin concentrations. This can cause severe hypotension, syncope and profound sedation.
How serious is the interaction between Cobicistat and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Avoid starting flibanserin until at least 2 weeks after stopping the inhibitor.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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