Drug interactions
Ceritinib + Flibanserin
Severity: Contraindicated
Ceritinib and Flibanserin: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a strong CYP3A4 inhibitor and may markedly raise flibanserin concentrations. This can cause severe hypotension, syncope and profound sedation.
What this interaction means in plain words
Ceritinib and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ceritinib belongs to Oncology; Flibanserin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 metabolism of flibanserin increases its exposure.
What to do
Do not coadminister. Avoid starting flibanserin until at least 2 weeks after stopping the inhibitor.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceritinib and Flibanserin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
- Cyclosporine + Flibanserin Contraindicated
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Ado-trastuzumab + Ceritinib Major
Frequently asked questions
Can I take Ceritinib with Flibanserin?
MediHelp rates the interaction as contraindicated. Ceritinib and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ceritinib is a strong CYP3A4 inhibitor and may markedly raise flibanserin concentrations. This can cause severe hypotension, syncope and profound sedation.
How serious is the interaction between Ceritinib and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Avoid starting flibanserin until at least 2 weeks after stopping the inhibitor.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Flibanserin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
