Drug interactions
Amlodipine-olmesartan + Furosemide
Severity: Moderate
Amlodipine-olmesartan and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide adds to the blood pressure lowering effect of olmesartan and amlodipine, and volume depletion increases the risk of hypotension and acute kidney injury with an ARB. Potassium effects oppose each other and are usually manageable.
What this interaction means in plain words
Amlodipine-olmesartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion activates the renin-angiotensin system, increasing dependence on angiotensin II and enhancing ARB hypotensive and renal effects.
What to do
Monitor blood pressure, renal function and electrolytes when starting or adjusting either drug, and consider reducing the diuretic dose if hypotension or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Furosemide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide adds to the blood pressure lowering effect of olmesartan and amlodipine, and volume depletion increases the risk of hypotension and acute kidney injury with an ARB. Potassium effects oppose each other and are usually manageable.
How serious is the interaction between Amlodipine-olmesartan and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes when starting or adjusting either drug, and consider reducing the diuretic dose if hypotension or volume depletion occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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