Drug interactions
Amlodipine-olmesartan + Itraconazole
Severity: Moderate
Amlodipine-olmesartan and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits CYP3A4 and can substantially increase amlodipine concentrations, causing hypotension, peripheral edema and tachycardia. Itraconazole also has negative inotropic effects that may worsen heart failure when combined with calcium channel blockers.
What this interaction means in plain words
Amlodipine-olmesartan and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4-mediated amlodipine metabolism, with additive negative inotropy.
What to do
Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if needed. Avoid in patients with heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Itraconazole?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole inhibits CYP3A4 and can substantially increase amlodipine concentrations, causing hypotension, peripheral edema and tachycardia. Itraconazole also has negative inotropic effects that may worsen heart failure when combined with calcium channel blockers.
How serious is the interaction between Amlodipine-olmesartan and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and reduce the amlodipine dose if needed. Avoid in patients with heart failure.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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