Drug interactions
Dihydroergotamine + Itraconazole
Severity: Contraindicated
Dihydroergotamine and Itraconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole markedly raises dihydroergotamine concentrations. This can cause serious ergotism with severe vasospasm and cerebral or limb ischemia.
What this interaction means in plain words
Dihydroergotamine and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Itraconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces dihydroergotamine metabolism.
What to do
Do not use together. Choose a non-ergot migraine therapy during and for a period after itraconazole.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Disopyramide + Itraconazole Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Itraconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole markedly raises dihydroergotamine concentrations. This can cause serious ergotism with severe vasospasm and cerebral or limb ischemia.
How serious is the interaction between Dihydroergotamine and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Choose a non-ergot migraine therapy during and for a period after itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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