Drug interactions
Conivaptan + Itraconazole
Severity: Contraindicated
Conivaptan and Itraconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 substrate and itraconazole is a strong CYP3A4 inhibitor, so conivaptan exposure rises markedly. This may cause excessively rapid sodium correction with risk of osmotic demyelination.
What this interaction means in plain words
Conivaptan and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Strong CYP3A4 inhibition by itraconazole reduces conivaptan clearance.
What to do
Do not combine. Use another hyponatremia treatment, and avoid conivaptan for about two weeks after stopping itraconazole.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
- Disopyramide + Itraconazole Contraindicated
Frequently asked questions
Can I take Conivaptan with Itraconazole?
MediHelp rates the interaction as contraindicated. Conivaptan and Itraconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Conivaptan is a CYP3A4 substrate and itraconazole is a strong CYP3A4 inhibitor, so conivaptan exposure rises markedly. This may cause excessively rapid sodium correction with risk of osmotic demyelination.
How serious is the interaction between Conivaptan and Itraconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use another hyponatremia treatment, and avoid conivaptan for about two weeks after stopping itraconazole.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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