Drug interactions
Amlodipine-olmesartan + Labetalol
Severity: Moderate
Amlodipine-olmesartan and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labetalol adds antihypertensive effect to amlodipine and olmesartan, which may cause excessive hypotension, dizziness or bradycardia. The combination is often used deliberately but needs dose titration.
What this interaction means in plain words
Amlodipine-olmesartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic lowering of blood pressure through alpha/beta blockade, calcium channel blockade and angiotensin receptor blockade.
What to do
Monitor blood pressure and heart rate during initiation and titration, and reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Labetalol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Labetalol adds antihypertensive effect to amlodipine and olmesartan, which may cause excessive hypotension, dizziness or bradycardia. The combination is often used deliberately but needs dose titration.
How serious is the interaction between Amlodipine-olmesartan and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and titration, and reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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