Drug interactions
Amlodipine-olmesartan + Letermovir
Severity: Moderate
Amlodipine-olmesartan and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/1B3 and may raise olmesartan plasma concentrations. This can enhance blood pressure lowering and renal effects of olmesartan.
What this interaction means in plain words
Amlodipine-olmesartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake by letermovir decreases olmesartan clearance.
What to do
Monitor blood pressure and renal function during letermovir therapy, and lower the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Letermovir?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits OATP1B1/1B3 and may raise olmesartan plasma concentrations. This can enhance blood pressure lowering and renal effects of olmesartan.
How serious is the interaction between Amlodipine-olmesartan and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during letermovir therapy, and lower the olmesartan dose if hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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