Drug interactions
Amlodipine-olmesartan + Lomitapide
Severity: Moderate
Amlodipine-olmesartan and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling advises limiting the dose with weak CYP3A4 inhibitors.
What this interaction means in plain words
Amlodipine-olmesartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Amlodipine weakly inhibits CYP3A4, reducing lomitapide first-pass and systemic metabolism.
What to do
Limit the lomitapide dose as per labeling when weak CYP3A4 inhibitors are used, and monitor liver enzymes and gastrointestinal tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Lomitapide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may increase lomitapide exposure, raising the risk of hepatotoxicity and gastrointestinal adverse effects. Lomitapide labeling advises limiting the dose with weak CYP3A4 inhibitors.
How serious is the interaction between Amlodipine-olmesartan and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the lomitapide dose as per labeling when weak CYP3A4 inhibitors are used, and monitor liver enzymes and gastrointestinal tolerance.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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