Drug interactions
Ensitrelvir + Lomitapide
Severity: Contraindicated
Ensitrelvir and Lomitapide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ensitrelvir can markedly raise lomitapide levels through CYP3A inhibition. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
What this interaction means in plain words
Ensitrelvir and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ensitrelvir belongs to Anti Virals; Lomitapide belongs to Cardiovascular.
Why it happens
CYP3A inhibition decreases lomitapide metabolism.
What to do
Do not co-administer; choose an alternative COVID-19 therapy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ensitrelvir
- Apalutamide + Ensitrelvir Contraindicated
- Carbamazepine + Ensitrelvir Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Erythromycin + Lomitapide Contraindicated
Frequently asked questions
Can I take Ensitrelvir with Lomitapide?
MediHelp rates the interaction as contraindicated. Ensitrelvir and Lomitapide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ensitrelvir can markedly raise lomitapide levels through CYP3A inhibition. This increases the risk of hepatotoxicity and gastrointestinal adverse effects.
How serious is the interaction between Ensitrelvir and Lomitapide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative COVID-19 therapy.
What other medicines interact with Ensitrelvir?
MediHelp also lists interactions of Ensitrelvir with, for example, Apalutamide, Carbamazepine, Colchicine. The full list is on the Ensitrelvir page.
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