Drug interactions
Amlodipine-olmesartan + Mefloquine
Severity: Moderate
Amlodipine-olmesartan and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine may affect cardiac conduction and cause bradycardia, and combining it with calcium channel blockers could add to conduction effects. A pharmacokinetic increase in amlodipine is not well established.
What this interaction means in plain words
Amlodipine-olmesartan and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive effects on cardiac conduction and possible CYP3A4 involvement; the mechanism is not firmly established.
What to do
Monitor heart rate and blood pressure, and obtain an ECG if palpitations, syncope or bradycardia occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Mefloquine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine may affect cardiac conduction and cause bradycardia, and combining it with calcium channel blockers could add to conduction effects. A pharmacokinetic increase in amlodipine is not well established.
How serious is the interaction between Amlodipine-olmesartan and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and obtain an ECG if palpitations, syncope or bradycardia occur.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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