Drug interactions
Dronedarone + Mefloquine
Severity: Contraindicated
Dronedarone and Mefloquine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone markedly prolongs the QT interval and mefloquine may add to this, raising the risk of torsades de pointes. Dronedarone labeling advises against combination with other QT-prolonging drugs.
What this interaction means in plain words
Dronedarone and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with dronedarone being a potent hERG blocker.
What to do
Do not combine; use a non-QT-prolonging antimalarial. If mefloquine is essential, discuss stopping dronedarone with a cardiologist.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
- Mefloquine + Quinidine Contraindicated
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Mefloquine?
MediHelp rates the interaction as contraindicated. Dronedarone and Mefloquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronedarone markedly prolongs the QT interval and mefloquine may add to this, raising the risk of torsades de pointes. Dronedarone labeling advises against combination with other QT-prolonging drugs.
How serious is the interaction between Dronedarone and Mefloquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging antimalarial. If mefloquine is essential, discuss stopping dronedarone with a cardiologist.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Ibutilide, Levoketoconazole. The full list is on the Mefloquine page.
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