Drug interactions
Amlodipine-olmesartan + Piroxicam
Severity: Moderate
Amlodipine-olmesartan and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam can reduce the blood pressure lowering effect of olmesartan and increase the risk of renal impairment and hyperkalemia when combined with an angiotensin receptor blocker. Older and volume-depleted patients are most at risk.
What this interaction means in plain words
Amlodipine-olmesartan and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Piroxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, opposing ARB effects.
What to do
Avoid prolonged use where possible and keep the patient well hydrated. Monitor blood pressure, creatinine and potassium after starting the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Piroxicam?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam can reduce the blood pressure lowering effect of olmesartan and increase the risk of renal impairment and hyperkalemia when combined with an angiotensin receptor blocker. Older and volume-depleted patients are most at risk.
How serious is the interaction between Amlodipine-olmesartan and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged use where possible and keep the patient well hydrated. Monitor blood pressure, creatinine and potassium after starting the NSAID.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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