Drug interactions
Amlodipine-olmesartan + Tacrolimus
Severity: Moderate
Amlodipine-olmesartan and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amlodipine is a weak CYP3A4 inhibitor and may modestly raise tacrolimus exposure in some transplant patients. Separately, both tacrolimus and olmesartan can raise potassium and affect renal function, which adds to the monitoring burden.
What this interaction means in plain words
Amlodipine-olmesartan and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Possible weak CYP3A4 inhibition by amlodipine reduces tacrolimus metabolism, while tacrolimus-induced renal effects and olmesartan add to hyperkalemia risk.
What to do
Monitor tacrolimus trough levels after starting or changing amlodipine and adjust the tacrolimus dose accordingly. Monitor serum potassium and creatinine regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan with Tacrolimus?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amlodipine is a weak CYP3A4 inhibitor and may modestly raise tacrolimus exposure in some transplant patients. Separately, both tacrolimus and olmesartan can raise potassium and affect renal function, which adds to the monitoring burden.
How serious is the interaction between Amlodipine-olmesartan and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tacrolimus trough levels after starting or changing amlodipine and adjust the tacrolimus dose accordingly. Monitor serum potassium and creatinine regularly.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
