Drug interactions
Amlodipine-olmesartan + Tizanidine
Severity: Moderate
Amlodipine-olmesartan and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is an alpha-2 agonist that lowers blood pressure and can cause hypotension and bradycardia, adding to amlodipine and olmesartan. Dizziness and syncope are most likely at initiation or dose increases.
What this interaction means in plain words
Amlodipine-olmesartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Central alpha-2 agonism reduces sympathetic outflow, additive to other antihypertensive mechanisms.
What to do
Monitor blood pressure and heart rate when starting or increasing tizanidine, and use the lowest effective dose. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amifostine + Amlodipine-olmesartan Major
- Amiloride + Amlodipine-olmesartan Major
- Amlodipine-olmesartan + Benazepril Major
- Amlodipine-olmesartan + Captopril Major
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Amlodipine-olmesartan with Tizanidine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is an alpha-2 agonist that lowers blood pressure and can cause hypotension and bradycardia, adding to amlodipine and olmesartan. Dizziness and syncope are most likely at initiation or dose increases.
How serious is the interaction between Amlodipine-olmesartan and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or increasing tizanidine, and use the lowest effective dose. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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