Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Arformoterol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Arformoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Arformoterol, a long-acting beta-2 agonist, can lower serum potassium and may cause ECG changes, and hydrochlorothiazide adds to potassium loss. The combination may increase the risk of hypokalemia and arrhythmia, especially in patients with COPD and hypoxia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Arformoterol belongs to Respiratory.
Why it happens
Beta-2 stimulated cellular potassium uptake combines with thiazide-induced renal potassium wasting.
What to do
Monitor serum potassium and magnesium periodically and correct deficits. Take extra care in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Arformoterol
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Arformoterol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Arformoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Arformoterol, a long-acting beta-2 agonist, can lower serum potassium and may cause ECG changes, and hydrochlorothiazide adds to potassium loss. The combination may increase the risk of hypokalemia and arrhythmia, especially in patients with COPD and hypoxia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Arformoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically and correct deficits. Take extra care in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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