Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Artemether / lumefantrine
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Artemether / lumefantrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Artemether may weakly induce CYP3A4, which could lower amlodipine concentrations during a short antimalarial course. Any loss of blood pressure control is expected to be small and temporary.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 induction increases amlodipine metabolism.
What to do
Monitor blood pressure during and shortly after the antimalarial course; no preemptive dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Artemether / lumefantrine?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Artemether / lumefantrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Artemether may weakly induce CYP3A4, which could lower amlodipine concentrations during a short antimalarial course. Any loss of blood pressure control is expected to be small and temporary.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Artemether / lumefantrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during and shortly after the antimalarial course; no preemptive dose change is usually needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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