Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Aspirin / citric acid / sodium bicarbonate
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Aspirin / citric acid / sodium bicarbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Effervescent aspirin at analgesic doses can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide and increase the risk of acute kidney injury, especially in elderly or volume-depleted patients. Potassium may also rise. The sodium bicarbonate load can add sodium and further oppose blood pressure control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibits vasodilatory renal prostaglandins, causing sodium and fluid retention and reduced glomerular perfusion when combined with an ARB and diuretic.
What to do
Monitor blood pressure, renal function and potassium if used regularly, and keep patients well hydrated. Prefer paracetamol for occasional analgesia where suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Aspirin / citric acid / sodium bicarbonate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Aspirin / citric acid / sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Effervescent aspirin at analgesic doses can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide and increase the risk of acute kidney injury, especially in elderly or volume-depleted patients. Potassium may also rise. The sodium bicarbonate load can add sodium and further oppose blood pressure control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Aspirin / citric acid / sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium if used regularly, and keep patients well hydrated. Prefer paracetamol for occasional analgesia where suitable.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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