Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Aspirin rectal
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Aspirin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rectal aspirin, particularly at analgesic doses, can blunt the blood pressure lowering effect of olmesartan and hydrochlorothiazide and may reduce renal function in volume-depleted or elderly patients. Combining an angiotensin receptor blocker with an NSAID-type drug can also raise potassium, although the thiazide partly offsets this.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate inhibits renal prostaglandin synthesis, reducing renal perfusion, sodium excretion and antihypertensive efficacy while impairing potassium handling.
What to do
Monitor blood pressure, serum creatinine and potassium when regular aspirin at analgesic doses is used, and ensure adequate hydration. Low-dose cardioprotective aspirin rarely needs any change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Aspirin rectal?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Aspirin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rectal aspirin, particularly at analgesic doses, can blunt the blood pressure lowering effect of olmesartan and hydrochlorothiazide and may reduce renal function in volume-depleted or elderly patients. Combining an angiotensin receptor blocker with an NSAID-type drug can also raise potassium, although the thiazide partly offsets this.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Aspirin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when regular aspirin at analgesic doses is used, and ensure adequate hydration. Low-dose cardioprotective aspirin rarely needs any change.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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