Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Bretylium
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Bretylium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bretylium frequently causes hypotension through adrenergic neuron blockade, and antihypertensives and diuretics may worsen this. Orthostatic hypotension can be significant, particularly with volume depletion.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from adrenergic neuron blockade plus vasodilation, RAS blockade and diuresis.
What to do
Monitor blood pressure closely and correct volume depletion; reduce or hold antihypertensive doses if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Bretylium?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Bretylium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bretylium frequently causes hypotension through adrenergic neuron blockade, and antihypertensives and diuretics may worsen this. Orthostatic hypotension can be significant, particularly with volume depletion.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Bretylium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely and correct volume depletion; reduce or hold antihypertensive doses if hypotension develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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