Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Buprenorphine long-acting
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Buprenorphine long-acting: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can stimulate antidiuretic hormone release, which may blunt the diuretic effect of hydrochlorothiazide. Opioids also add to hypotension and orthostatic effects of antihypertensives. The clinical effect is generally modest.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Buprenorphine long-acting have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release causes fluid retention, and additive hypotensive effects occur.
What to do
Monitor blood pressure, fluid status and edema, and adjust the diuretic dose if efficacy declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Buprenorphine long-acting, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Buprenorphine long-acting?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Buprenorphine long-acting have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can stimulate antidiuretic hormone release, which may blunt the diuretic effect of hydrochlorothiazide. Opioids also add to hypotension and orthostatic effects of antihypertensives. The clinical effect is generally modest.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Buprenorphine long-acting?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and edema, and adjust the diuretic dose if efficacy declines.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
