Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Butalbital
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce amlodipine exposure, potentially weakening blood pressure control with prolonged use. Additive orthostatic hypotension and sedation may also occur.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increases amlodipine clearance, with additive hypotensive and sedative effects.
What to do
Monitor blood pressure with regular butalbital use and adjust the antihypertensive regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Butalbital?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and reduce amlodipine exposure, potentially weakening blood pressure control with prolonged use. Additive orthostatic hypotension and sedation may also occur.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure with regular butalbital use and adjust the antihypertensive regimen if control worsens.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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