Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Calcium chloride
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Calcium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium can antagonize the effects of calcium channel blockers and has been used to reverse calcium channel blocker toxicity. Thiazides also lower urinary calcium excretion, raising hypercalcemia risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated extracellular calcium overcomes L-type calcium channel blockade by amlodipine; thiazide reduces calcium excretion.
What to do
Monitor blood pressure and serum calcium when parenteral calcium is given. Expect reduced amlodipine effect during calcium infusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcium chloride?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Calcium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous calcium can antagonize the effects of calcium channel blockers and has been used to reverse calcium channel blocker toxicity. Thiazides also lower urinary calcium excretion, raising hypercalcemia risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum calcium when parenteral calcium is given. Expect reduced amlodipine effect during calcium infusion.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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