Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Calcium citrate
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Calcium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium supplements seldom reduce amlodipine's antihypertensive effect meaningfully. The thiazide component reduces urinary calcium loss, so hypercalcemia can occur with high calcium intake.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical functional antagonism of calcium channel blockade by calcium; thiazide-reduced calcium excretion.
What to do
Monitor serum calcium periodically, particularly with high supplement doses or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Calcium citrate?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral calcium supplements seldom reduce amlodipine's antihypertensive effect meaningfully. The thiazide component reduces urinary calcium loss, so hypercalcemia can occur with high calcium intake.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Calcium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, particularly with high supplement doses or renal impairment.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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