Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Carbenoxolone
Severity: Major
Amlodipine-olmesartan-hydrochlorothiazide and Carbenoxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes sodium retention and potassium loss, adding to thiazide-induced hypokalemia. It may also raise blood pressure and counter antihypertensive therapy.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of 11-beta-hydroxysteroid dehydrogenase causes mineralocorticoid excess, with additive renal potassium wasting alongside the thiazide.
What to do
Avoid the combination where possible; otherwise monitor potassium and blood pressure regularly and correct hypokalemia promptly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Carbenoxolone?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Carbenoxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity that causes sodium retention and potassium loss, adding to thiazide-induced hypokalemia. It may also raise blood pressure and counter antihypertensive therapy.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Carbenoxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; otherwise monitor potassium and blood pressure regularly and correct hypokalemia promptly.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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