Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Carvedilol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol adds to the blood pressure lowering of this combination through beta and alpha-1 blockade, increasing the risk of hypotension and dizziness. Beta-blockers may modestly raise potassium while thiazides lower it.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic blood pressure lowering through beta and alpha-1 blockade with the antihypertensives.
What to do
Monitor blood pressure, heart rate and potassium when starting or titrating. Reduce doses if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Carvedilol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol adds to the blood pressure lowering of this combination through beta and alpha-1 blockade, increasing the risk of hypotension and dizziness. Beta-blockers may modestly raise potassium while thiazides lower it.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and potassium when starting or titrating. Reduce doses if symptomatic hypotension or bradycardia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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