Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Cefamandole
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Cefamandole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole and hydrochlorothiazide are both secreted by renal tubular anion transporters, so competition may modestly raise levels of either drug. Clinical consequences are generally small.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Cefamandole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
No routine adjustment is needed; monitor renal function and blood pressure in patients with impaired kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Cefamandole?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Cefamandole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefamandole and hydrochlorothiazide are both secreted by renal tubular anion transporters, so competition may modestly raise levels of either drug. Clinical consequences are generally small.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Cefamandole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and blood pressure in patients with impaired kidney function.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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