Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Ceftobiprole medocaril
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Ceftobiprole medocaril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 and may raise olmesartan exposure. The clinical effect is likely modest and mostly relates to enhanced blood pressure lowering.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake of olmesartan.
What to do
Monitor blood pressure and renal function during the course of ceftobiprole. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Ceftobiprole medocaril?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits OATP1B1 and OATP1B3 and may raise olmesartan exposure. The clinical effect is likely modest and mostly relates to enhanced blood pressure lowering.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Ceftobiprole medocaril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during the course of ceftobiprole. No routine dose change is needed.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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