Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Celiprolol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Celiprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol adds to the blood pressure lowering of the triple combination, which may cause hypotension or bradycardia. Hydrochlorothiazide can also reduce oral celiprolol absorption, which may lessen its effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive pharmacodynamic effects, plus reduced intestinal absorption of celiprolol with hydrochlorothiazide.
What to do
Monitor blood pressure and heart rate when starting or changing doses and adjust therapy based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Celiprolol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Celiprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol adds to the blood pressure lowering of the triple combination, which may cause hypotension or bradycardia. Hydrochlorothiazide can also reduce oral celiprolol absorption, which may lessen its effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Celiprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or changing doses and adjust therapy based on response.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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