Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Cenobamate
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce amlodipine concentrations. This can lessen blood pressure lowering effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Cenobamate belongs to Central Nervous System.
Why it happens
CYP3A4 induction by cenobamate increases amlodipine clearance.
What to do
Monitor blood pressure and increase the amlodipine dose as needed; reassess if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Cenobamate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce amlodipine concentrations. This can lessen blood pressure lowering effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and increase the amlodipine dose as needed; reassess if cenobamate is stopped.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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