Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Choline magnesium trisalicylate
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide and increase the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Potassium may also rise.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces glomerular perfusion and sodium excretion in patients on an ARB and diuretic.
What to do
Monitor blood pressure, serum creatinine and potassium, maintain hydration, and use the lowest effective salicylate dose for the shortest period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide and increase the risk of acute kidney injury, particularly in elderly or volume-depleted patients. Potassium may also rise.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, maintain hydration, and use the lowest effective salicylate dose for the shortest period.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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