Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Citalopram
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and SSRIs can cause hyponatremia, and together the risk is increased, particularly in older adults. Thiazide-induced hypokalemia and hypomagnesemia may also add to citalopram-related QT prolongation risk.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Citalopram belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: thiazide-induced renal sodium loss plus SSRI-associated SIADH; electrolyte depletion can potentiate QT effects.
What to do
Check serum sodium, potassium and magnesium at baseline and after starting or changing therapy, especially in the elderly. Correct electrolyte abnormalities and consider an ECG if risk factors for QT prolongation are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Citalopram?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and SSRIs can cause hyponatremia, and together the risk is increased, particularly in older adults. Thiazide-induced hypokalemia and hypomagnesemia may also add to citalopram-related QT prolongation risk.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium, potassium and magnesium at baseline and after starting or changing therapy, especially in the elderly. Correct electrolyte abnormalities and consider an ECG if risk factors for QT prolongation are present.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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