Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Conivaptan
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may raise amlodipine levels. This can cause hypotension and edema, and the diuretic and fluid shifts from conivaptan add to volume-related blood pressure changes.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibition of CYP3A4 reduces amlodipine clearance.
What to do
Monitor blood pressure and heart rate during conivaptan infusion and reduce the amlodipine dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Conivaptan?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may raise amlodipine levels. This can cause hypotension and edema, and the diuretic and fluid shifts from conivaptan add to volume-related blood pressure changes.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during conivaptan infusion and reduce the amlodipine dose if hypotension develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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