Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Cyclosporine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both thiazide diuretics and cyclosporine can contribute to electrolyte disturbances, and thiazides may worsen hyperuricemia and renal effects seen with cyclosporine. Amlodipine may modestly raise cyclosporine levels, and olmesartan with cyclosporine can raise potassium.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive electrolyte and renal effects, with minor CYP3A4 and P-gp related pharmacokinetic influence on cyclosporine.
What to do
Monitor serum sodium, potassium, magnesium, creatinine and cyclosporine trough levels. Adjust cyclosporine dose according to levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Cyclosporine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both thiazide diuretics and cyclosporine can contribute to electrolyte disturbances, and thiazides may worsen hyperuricemia and renal effects seen with cyclosporine. Amlodipine may modestly raise cyclosporine levels, and olmesartan with cyclosporine can raise potassium.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium, magnesium, creatinine and cyclosporine trough levels. Adjust cyclosporine dose according to levels.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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