Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Dichlorphenamide
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium loss and metabolic acidosis. With hydrochlorothiazide, hypokalemia can be additive and may provoke arrhythmias or weakness.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Additive kaliuresis from carbonic anhydrase inhibition and thiazide diuresis.
What to do
Monitor serum potassium and bicarbonate regularly and supplement potassium as needed. Reassess the diuretic regimen if hypokalemia persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Dichlorphenamide?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide, a carbonic anhydrase inhibitor, causes renal potassium loss and metabolic acidosis. With hydrochlorothiazide, hypokalemia can be additive and may provoke arrhythmias or weakness.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and bicarbonate regularly and supplement potassium as needed. Reassess the diuretic regimen if hypokalemia persists.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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