Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Diltiazem
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem raises amlodipine exposure, which can increase hypotension, edema and reflex symptoms. Combining a dihydropyridine with diltiazem is sometimes done on purpose, but needs dose awareness and monitoring.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4 and reduces first-pass and systemic metabolism of amlodipine, with additive vasodilatory effects.
What to do
Monitor blood pressure, heart rate and edema, and lower the amlodipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Diltiazem?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem raises amlodipine exposure, which can increase hypotension, edema and reflex symptoms. Combining a dihydropyridine with diltiazem is sometimes done on purpose, but needs dose awareness and monitoring.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and edema, and lower the amlodipine dose if hypotension or marked edema develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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