Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Doxazosin
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Doxazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxazosin and the antihypertensive combination lower blood pressure by different mechanisms, so the effect is additive. This can cause symptomatic hypotension, dizziness or syncope, especially after the first doxazosin dose.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Doxazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation and blood pressure lowering from alpha-1 blockade plus calcium channel blockade, ARB and diuretic.
What to do
Start doxazosin at a low dose, preferably at bedtime, and titrate while monitoring standing and sitting blood pressure. Counsel patients about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Doxazosin?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Doxazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxazosin and the antihypertensive combination lower blood pressure by different mechanisms, so the effect is additive. This can cause symptomatic hypotension, dizziness or syncope, especially after the first doxazosin dose.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Doxazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start doxazosin at a low dose, preferably at bedtime, and titrate while monitoring standing and sitting blood pressure. Counsel patients about orthostatic symptoms.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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