Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Encorafenib
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib both inhibits and induces CYP3A4, so amlodipine exposure may rise or fall unpredictably. Encorafenib also inhibits OATP1B1/1B3, which may modestly increase olmesartan levels.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib, plus OATP1B1/1B3 inhibition affecting olmesartan uptake.
What to do
Monitor blood pressure and for edema or hypotension, and adjust antihypertensive doses according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Encorafenib
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Encorafenib?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib both inhibits and induces CYP3A4, so amlodipine exposure may rise or fall unpredictably. Encorafenib also inhibits OATP1B1/1B3, which may modestly increase olmesartan levels.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for edema or hypotension, and adjust antihypertensive doses according to response.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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