Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Epinephrine racemic
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine racemic: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can shift potassium into cells and may add to the potassium loss caused by hydrochlorothiazide. Its pressor effect may also oppose blood pressure control.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta2-mediated intracellular potassium shift combined with thiazide renal potassium wasting; adrenergic pressor effect.
What to do
Monitor serum potassium and blood pressure after systemic or repeated dosing, and replace potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Epinephrine racemic?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine racemic can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can shift potassium into cells and may add to the potassium loss caused by hydrochlorothiazide. Its pressor effect may also oppose blood pressure control.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine racemic?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure after systemic or repeated dosing, and replace potassium if low.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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