Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Epinephrine
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine drives potassium into cells via beta-2 receptors, and hydrochlorothiazide causes renal potassium loss. Combined use may produce hypokalemia that could contribute to arrhythmias.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Additive lowering of serum potassium from beta-2 mediated cellular uptake and thiazide kaliuresis.
What to do
Monitor serum potassium when epinephrine is used repeatedly or by infusion, and correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Epinephrine?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine drives potassium into cells via beta-2 receptors, and hydrochlorothiazide causes renal potassium loss. Combined use may produce hypokalemia that could contribute to arrhythmias.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium when epinephrine is used repeatedly or by infusion, and correct hypokalemia promptly.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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