Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Fenbufen
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenbufen, an NSAID, can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. Together with olmesartan it increases the risk of acute kidney injury and hyperkalemia, especially with volume depletion, advanced age or existing renal impairment.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, compounding the effects of ARB and diuretic.
What to do
Monitor blood pressure, serum creatinine and potassium, and maintain hydration. Use the shortest NSAID course or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Fenbufen?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenbufen, an NSAID, can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. Together with olmesartan it increases the risk of acute kidney injury and hyperkalemia, especially with volume depletion, advanced age or existing renal impairment.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and maintain hydration. Use the shortest NSAID course or choose an alternative analgesic.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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