Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Fentanyl intranasal
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may stimulate ADH release and reduce diuretic response to hydrochlorothiazide. Fentanyl can also add to hypotension and cause urinary retention. Clinical impact is usually small.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-related ADH release and additive hypotensive effects.
What to do
Monitor blood pressure, fluid balance and urinary symptoms, particularly in men with prostatic enlargement.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Fentanyl intranasal?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids may stimulate ADH release and reduce diuretic response to hydrochlorothiazide. Fentanyl can also add to hypotension and cause urinary retention. Clinical impact is usually small.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid balance and urinary symptoms, particularly in men with prostatic enlargement.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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