Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Fentanyl
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can cause hypotension and may add to the blood pressure lowering of this three-drug antihypertensive, particularly with orthostasis or volume depletion. Opioid-related antidiuretic effects and urinary retention may also blunt diuretic effect.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects, plus opioid-induced antidiuretic hormone release and urinary retention opposing diuresis.
What to do
Monitor blood pressure and volume status, and counsel on rising slowly. Watch for urinary retention, especially in men with prostatic enlargement.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Fentanyl?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can cause hypotension and may add to the blood pressure lowering of this three-drug antihypertensive, particularly with orthostasis or volume depletion. Opioid-related antidiuretic effects and urinary retention may also blunt diuretic effect.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and volume status, and counsel on rising slowly. Watch for urinary retention, especially in men with prostatic enlargement.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
