Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Formoterol
Severity: Moderate
Amlodipine-olmesartan-hydrochlorothiazide and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol and hydrochlorothiazide can both lower serum potassium. Combined use may produce clinically relevant hypokalemia, which can predispose to arrhythmias, especially with high formoterol doses or hypoxia.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Formoterol belongs to Respiratory.
Why it happens
Beta-2 agonists shift potassium into cells while thiazides cause renal potassium loss, giving additive hypokalemia.
What to do
Check serum potassium and magnesium in patients on regular formoterol and replace as needed. Take extra care in patients with severe asthma or COPD, or when other hypokalemic drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-olmesartan-hydrochlorothiazide and Formoterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Formoterol?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol and hydrochlorothiazide can both lower serum potassium. Combined use may produce clinically relevant hypokalemia, which can predispose to arrhythmias, especially with high formoterol doses or hypoxia.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium in patients on regular formoterol and replace as needed. Take extra care in patients with severe asthma or COPD, or when other hypokalemic drugs are used.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
