Drug interactions
Amlodipine-olmesartan-hydrochlorothiazide + Ganciclovir
Severity: Minor
Amlodipine-olmesartan-hydrochlorothiazide and Ganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganciclovir is eliminated mainly by the kidney, and thiazides could theoretically compete for tubular secretion and raise exposure. Dehydration or volume depletion from the diuretic may further reduce ganciclovir clearance, increasing the risk of hematologic toxicity.
What this interaction means in plain words
Amlodipine-olmesartan-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Ganciclovir belongs to Anti Virals.
Why it happens
Possible competition for renal tubular secretion and reduced renal clearance with volume depletion.
What to do
Dose ganciclovir according to creatinine clearance and monitor blood counts and renal function during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Ganciclovir?
MediHelp rates the interaction as minor. Amlodipine-olmesartan-hydrochlorothiazide and Ganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganciclovir is eliminated mainly by the kidney, and thiazides could theoretically compete for tubular secretion and raise exposure. Dehydration or volume depletion from the diuretic may further reduce ganciclovir clearance, increasing the risk of hematologic toxicity.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Ganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dose ganciclovir according to creatinine clearance and monitor blood counts and renal function during co-therapy.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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